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Correlates of excessive daytime sleepiness in de novo Parkinson's disease: A case control study
Movement disorders, 2015-09, Vol.30 (10), p.1371-1381
Simuni, Tanya
Caspell-Garcia, Chelsea
Coffey, Christopher
Chahine, Lama M.
Lasch, Shirley
Oertel, Wolfgang H.
Mayer, Geert
Högl, Birgit
Postuma, Ron
Videnovic, Aleksandar
Amara, Amy Willis
Marek, Ken
2015
Details
Autor(en) / Beteiligte
Simuni, Tanya
Caspell-Garcia, Chelsea
Coffey, Christopher
Chahine, Lama M.
Lasch, Shirley
Oertel, Wolfgang H.
Mayer, Geert
Högl, Birgit
Postuma, Ron
Videnovic, Aleksandar
Amara, Amy Willis
Marek, Ken
Titel
Correlates of excessive daytime sleepiness in de novo Parkinson's disease: A case control study
Ist Teil von
Movement disorders, 2015-09, Vol.30 (10), p.1371-1381
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2015
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Objective This study was undertaken to determine the frequency and correlates of excessive daytime sleepiness in de novo, untreated Parkinson's disease (PD) patients compared with the matched healthy controls. Methods Data were obtained from the Parkinson's Progression Markers Initiative, an international study of de novo, untreated PD patients and healthy controls. At baseline, participants were assessed with a wide range of motor and nonmotor scales, including the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS‐UPDRS). Excessive daytime sleepiness was assessed based on the Epworth Sleepiness scale (ESS), with a cutoff of 10. Results Four hundred twenty‐three PD subjects and 196 healthy controls were recruited into the study. Mean ESS (min, max) score was 5.8 (0, 20) for the PD subjects and 5.6 (0, 19) for healthy controls (P = 0.54). Sixty‐six (15.6%) PD subjects and 24 (12%) healthy controls had ESS of at least 10 (P = 0.28). No difference was seen in demographic characteristics, age of onset, disease duration, PD subtype, cognitive status, or utilization of sedatives between the PD sleepiness‐positive versus the negative group. The sleepiness‐positive group had higher MDS‐UPDRS Part I and II but not III scores, and higher depression and autonomic dysfunction scores. Sleepiness was associated with a marginal reduction of A‐beta (P = 0.05) but not alpha‐synuclein spinal fluid levels in PD. Conclusions This largest case control study demonstrates no difference in prevalence of excessive sleepiness in subjects with de novo untreated PD compared with healthy controls. The only clinical correlates of sleepiness were mood and autonomic dysfunction. Ongoing longitudinal analyses will be essential to further examine clinical and biological correlates of sleepiness in PD and specifically the role of dopaminergic therapy. © 2015 International Parkinson and Movement Disorder Society
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185
eISSN: 1531-8257
DOI: 10.1002/mds.26248
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4822999
Format
–
Schlagworte
Adult
,
Aged
,
Aged, 80 and over
,
biomarkers
,
Case-Control Studies
,
Comorbidity
,
daytime somnolence
,
Disorders of Excessive Somnolence - diagnosis
,
Disorders of Excessive Somnolence - epidemiology
,
Female
,
Humans
,
Male
,
Middle Aged
,
Parkinson Disease - diagnosis
,
Parkinson Disease - epidemiology
,
Parkinson's disease
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