Details

Autor(en) / Beteiligte

• Huang, Xiaodong
• Dixit, Vishva M

Titel

Drugging the undruggables： exploring the ubiquitin system for drug development

Ist Teil von

• Cell research, 2016-04, Vol.26 (4), p.484-498

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Dynamic modulation of protein levels is tightly controlled in response to physiological cues. In mammalian cells, much of the protein degradation is carried out by the ubiquitin-proteasome system （UPS）. Similar to kinases, com- ponents of the ubiquitin system are often dysregulated, leading to a variety of diseases, including cancer and neuro- degeneration, making them attractive drug targets. However, so far there are only a handful of drugs targeting the ubiquitin system that have been approved by the FDA. Here, we review possible therapeutic intervention nodes in the ubiquitin system, analyze the challenges, and highlight the most promising strategoies to targoet the UPS.