Details

Autor(en) / Beteiligte

• Murphy, Timothy P
• Cooper, Christopher J
• Cutlip, Donald E
• Matsumoto, Alan
• Jamerson, Kenneth
• Rundback, John
• Rosenfield, Kenneth A
• Henrich, William
• Shapiro, Joseph
• Massaro, Joseph
• Yen, Chen-Hsing
• Burtch, Holly
• Thum, Claudia
• Reid, Diane
• Dworkin, Lance

Titel

Roll-in experience from the Cardiovascular Outcomes with Renal Atherosclerotic Lesions (CORAL) study

Ist Teil von

• Journal of vascular and interventional radiology, 2014-04, Vol.25 (4), p.511

Ort / Verlag

United States

Erscheinungsjahr

2014

Link zum Volltext

Beschreibungen/Notizen

• To describe the experience and results from the roll-in phase of the Cardiovascular Outcomes with Renal Atherosclerotic Lesions (CORAL) study. The CORAL roll-in database was used to describe the baseline characteristics of the patients in the roll-in cohort, all of whom underwent renal artery stent placement; to evaluate CORAL site performance; to compare estimates of lesion (stenosis) severity made by site interventionalists with the central CORAL angiographic core laboratory readings; and to report outcomes after renal artery stent placement. During the roll-in phase, 239 patients (mean age, 70.2 y ± 9.0; 49% male) underwent renal artery stent procedures. Angiographic core laboratory analysis of renal arteriograms was done, and participants were followed at 1 month and 9 months. Major angiographic complications were identified in 28 (13%) subjects. Kidney function remained unchanged at the short (2-4 weeks) follow-up interval. Improvement in systolic blood pressure with use of distal embolic protection devices (n = 161) did not show any clinical benefit over nonuse of such devices (n = 78) in this small series. At 9 months, there were significantly more endpoints reported by site in subjects with bilateral renal artery stenosis (P = .01) and prior history of stroke (P = .03). In the roll-in phase of the CORAL study, a significant number of angiographic complications were identified. No effect was seen on estimated glomerular filtration rate after renal artery stent placement, but systolic blood pressure decreased significantly.