Details

Autor(en) / Beteiligte

• You, Dong Gil
• Deepagan, V G
• Um, Wooram
• Jeon, Sangmin
• Son, Sejin
• Chang, Hyeyoun
• Yoon, Hwa In
• Cho, Yong Woo
• Swierczewska, Maggie
• Lee, Seulki
• Pomper, Martin G
• Kwon, Ick Chan
• Kim, Kwangmeyung
• Park, Jae Hyung

Titel

ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer

Ist Teil von

• Scientific reports, 2016-03, Vol.6 (1), p.23200, Article 23200

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The non-invasive photodynamic therapy has been limited to treat superficial tumours, primarily ascribed to poor tissue penetration of light as the energy source. Herein, we designed a long-circulating hydrophilized titanium dioxide nanoparticle (HTiO2 NP) that can be activated by ultrasound to generate reactive oxygen species (ROS). When administered systemically to mice, HTiO2 NPs effectively suppressed the growth of superficial tumours after ultrasound treatments. In tumour tissue, the levels of proinflammatory cytokines were elevated several fold and intense vascular damage was observed. Notably, ultrasound treatments with HTiO2 NPs also suppressed the growth of deeply located liver tumours at least 15-fold, compared to animals without ultrasound treatments. This study provides the first demonstration of the feasibility of using HTiO2 NPs as sensitizers for sonodynamic therapy in vivo.