Details

Autor(en) / Beteiligte

• Charbonneau, Mark R.
• O’Donnell, David
• Blanton, Laura V.
• Totten, Sarah M.
• Davis, Jasmine C.C.
• Barratt, Michael J.
• Cheng, Jiye
• Guruge, Janaki
• Talcott, Michael
• Bain, James R.
• Muehlbauer, Michael J.
• Ilkayeva, Olga
• Wu, Chao
• Struckmeyer, Tedd
• Barile, Daniela
• Mangani, Charles
• Jorgensen, Josh
• Fan, Yue-mei
• Maleta, Kenneth
• Dewey, Kathryn G.
• Ashorn, Per
• Newgard, Christopher B.
• Lebrilla, Carlito
• Mills, David A.
• Gordon, Jeffrey I.

Titel

Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition

Ist Teil von

• Cell, 2016-02, Vol.164 (5), p.859-871

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Identifying interventions that more effectively promote healthy growth of children with undernutrition is a pressing global health goal. Analysis of human milk oligosaccharides (HMOs) from 6-month-postpartum mothers in two Malawian birth cohorts revealed that sialylated HMOs are significantly less abundant in those with severely stunted infants. To explore this association, we colonized young germ-free mice with a consortium of bacterial strains cultured from the fecal microbiota of a 6-month-old stunted Malawian infant and fed recipient animals a prototypic Malawian diet with or without purified sialylated bovine milk oligosaccharides (S-BMO). S-BMO produced a microbiota-dependent augmentation of lean body mass gain, changed bone morphology, and altered liver, muscle, and brain metabolism in ways indicative of a greater ability to utilize nutrients for anabolism. These effects were also documented in gnotobiotic piglets using the same consortium and Malawian diet. These preclinical models indicate a causal, microbiota-dependent relationship between S-BMO and growth promotion. [Display omitted] [Display omitted] •Malawian mothers with undernourished infants have decreased milk oligosaccharides•Sialylated milk sugars promote growth of animals colonized with infant microbiota•Growth promotion does not occur with provision of inulin or in germ-free mice•Sialylated oligosaccharides impact liver, muscle, and brain metabolism Two preclinical models for infant undernutrition establish a link between consumption of sialylated milk oligosaccharides, the gut microbiota, and healthy growth.