Details

Autor(en) / Beteiligte

• Price, C D
• Gibbs, A R
• Williams, W J

Titel

Halothane macrophage migration inhibtiion factor test in halothane-associated hepatitis

Ist Teil von

• Journal of clinical pathology, 1977-04, Vol.30 (4), p.312-316

Ort / Verlag

England: BMJ Publishing Group Ltd and Association of Clinical Pathologists

Erscheinungsjahr

1977

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• As an index of delayed hypersensitivity in vitro halothane macrophage migration inhibition factor tests (halothane-MIF tests) were performed on peripheral blood lymphocytes from five patients with halothane hepatitis. Twenty-two subjects exposed to halothane, but with no evidence of jaundice, five 'healthy' hospital anaesthetists, nine jaundiced subjects without halothane exposure, and 10 healthy subjects with no history of exposure to halothane were also tested. The halothane-MIF test was positive in four of the five patients with halothane-induced hepatitis; the negative result was in a patient on steroid treatment. The test was negative in all other subjects. Our findings suggest that the halothane-MIF test may be of value in the diagnosis of halothane-induced hepatitis and as a screeening procedure for the identification of susceptible subjects.