Details

Autor(en) / Beteiligte

• Lawrence, Monica G., MD
• Leiding, Jennifer W., MD
• Lyons, Jonathan J., MD
• Hsu, Amy P., BS
• Nelson, Celeste C., CRNP
• Jones, Nina, RN
• Fitzgerald, Alan, RN
• Chien, Wade W., MD
• Workman, Lisa, BA
• Platts-Mills, Thomas A., MD
• Brewer, Carmen, PhD
• Gafni, Rachel I., MD
• Stone, Kelly D., MD, PhD
• Milner, Joshua D., MD
• Holland, Steven M., MD

Titel

GATA3 haploinsufficiency does not block allergic sensitization or atopic disease

Ist Teil von

• Journal of allergy and clinical immunology, 2016-02, Vol.137 (2), p.627-629.e2

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Analysis of cytokine production by CD3+CD4+CD27-CD45RO+ effector memory T cells following stimulation with phorbol 12-myristate 13-acetate (PMA)/ionomycin demonstrated a trend toward an increased frequency of IFN-γ-producing cells and a trend toward a decreased frequency of IL-4- and IL-13-producing cells in patients (GATA3+/-) compared with healthy controls (GATA3wt), although there was wide variability and this did not reach statistical significance (Fig 1). Because previous reports have suggested a TH1 bias with a concomitant impairment in TH2 cytokine production,1 we next sought to determine whether there was a defect in TH2 differentiation.