Details

Autor(en) / Beteiligte

• Rudic, Boris
• Schimpf, Rainer
• Borggrefe, Martin

Titel

Short QT Syndrome - Review of Diagnosis and Treatment

Ist Teil von

• Arrhythmia & electrophysiology review, 2014-08, Vol.3 (2), p.76-79

Ort / Verlag

England: Radcliffe Medical Education Ltd

Erscheinungsjahr

2014

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Short QT syndrome (SQTS) is an inherited cardiac channelopathy characterised by an abnormally short QT interval and increased risk for atrial and ventricular arrhythmias. Diagnosis is based on the evaluation of symptoms (syncope or cardiac arrest), family history and electrocardiogram (ECG) findings. Mutations of cardiac ion channels responsible for the repolarisation orchestrate electrical heterogeneity during the action potential and provide substrate for triggering and maintaining of tachyarrhythmias. Due to the malignant natural history of SQTS, implantable cardioverter defibrillator (ICD) is the first-line therapy in affected patients. This review summarises current data and addresses the genetic basis and clinical features of SQTS.