Antimicrobial agents and chemotherapy, 2016-01, Vol.60 (1), p.44-51
2016
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Details
- Autor(en) / Beteiligte
- Titel
- Cooccurrence of Multiple AmpC β-Lactamases in Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis in Tunisia
- Ist Teil von
- Antimicrobial agents and chemotherapy, 2016-01, Vol.60 (1), p.44-51
- Ort / Verlag
- United States: American Society for Microbiology
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Over a period of 40 months, plasmid-mediated AmpC β-lactamases were detected in Tunis, Tunisia, in 78 isolates (0.59%) of Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. In 67 isolates, only one ampC gene was detected, i.e., blaCMY-2-type (n = 33), blaACC (n = 23), blaDHA (n = 6) or blaEBC (n = 5). Multiple ampC genes were detected in 11 isolates, with the following distribution: blaMOX-2, blaFOX-3, and blaCMY-4/16 (n = 6), blaFOX-3 and blaMOX-2 (n = 3), and blaCMY-4 and blaMOX-2 (n = 2). A great variety of plasmids carrying these genes was found, independently of the species and the bla gene. If the genetic context of blaCMY-2-type is variable, that of blaMOX-2, reported in part previously, is unique and that of blaFOX-3 is unique and new.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0066-4804eISSN: 1098-6596DOI: 10.1128/AAC.00828-15Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4704229
- Format
- –
- Schlagworte
- Aminoglycosides - pharmacology, Anti-Bacterial Agents - pharmacology, Bacterial Proteins, Bacterial Proteins - genetics, Bacterial Proteins - metabolism, Bacteriology, Base Sequence, beta-Lactamases, beta-Lactamases - genetics, beta-Lactamases - metabolism, Drug Resistance, Bacterial - genetics, Enterobacteriaceae Infections - epidemiology, Enterobacteriaceae Infections - microbiology, Escherichia coli, Escherichia coli - drug effects, Escherichia coli - enzymology, Escherichia coli - genetics, Escherichia coli - isolation & purification, Gene Expression, Humans, Klebsiella pneumoniae, Klebsiella pneumoniae - drug effects, Klebsiella pneumoniae - enzymology, Klebsiella pneumoniae - genetics, Klebsiella pneumoniae - isolation & purification, Life Sciences, Mechanisms of Resistance, Microbial Sensitivity Tests, Microbiology and Parasitology, Molecular Sequence Data, Penicillins - pharmacology, Plasmids, Plasmids - chemistry, Plasmids - metabolism, Proteus mirabilis, Proteus mirabilis - drug effects, Proteus mirabilis - enzymology, Proteus mirabilis - genetics, Proteus mirabilis - isolation & purification, Tunisia - epidemiology, Virulence Factors, Virulence Factors - genetics, Virulence Factors - metabolism