Antimicrobial agents and chemotherapy, 2016-01, Vol.60 (1), p.650-652
2016
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- Autor(en) / Beteiligte
- Titel
- Effect of High-Dose Antimicrobials on Biofilm Growth of Achromobacter Species Isolated from Cystic Fibrosis Patients
- Ist Teil von
- Antimicrobial agents and chemotherapy, 2016-01, Vol.60 (1), p.650-652
- Ort / Verlag
- United States: American Society for Microbiology
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- MICs and biofilm inhibitory concentrations (BICs) were measured for 68 cystic fibrosis (CF) Achromobacter isolates for amikacin, aztreonam, colistin, levofloxacin, and tobramycin. With the exception of colistin and levofloxacin, the remaining antibiotics had MIC90s, BICs at which 50% of the isolates were susceptible (BIC50s), and BICs at which 90% of the isolates were susceptible (BIC90s) equal to or above the highest concentrations tested. In a biofilm model, tobramycin was able to significantly increase killing of bacterial cells compared to controls, for intermediate-resistant strains only, at concentrations of 1,000 and 2,000 μg/ml.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0066-4804eISSN: 1098-6596DOI: 10.1128/AAC.02240-15Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4704188
- Format
- –
- Schlagworte
- Achromobacter, Achromobacter - drug effects, Achromobacter - isolation & purification, Achromobacter - physiology, Amikacin - pharmacology, Anti-Bacterial Agents, Anti-Bacterial Agents - pharmacology, Aztreonam - pharmacology, Biofilms, Biofilms - drug effects, Biofilms - growth & development, Colistin - pharmacology, Cystic Fibrosis, Cystic Fibrosis - complications, Cystic Fibrosis - microbiology, Gram-Negative Bacterial Infections, Gram-Negative Bacterial Infections - complications, Gram-Negative Bacterial Infections - microbiology, Humans, Levofloxacin - pharmacology, Microbial Sensitivity Tests, Plankton - drug effects, Plankton - growth & development, Susceptibility, Tobramycin - pharmacology