Details

Autor(en) / Beteiligte

• Morikawa, Toshio
• Ninomiya, Kiyofumi
• Akaki, Junji
• Kakihara, Namiko
• Kuramoto, Hiroyuki
• Matsumoto, Yurie
• Hayakawa, Takao
• Muraoka, Osamu
• Wang, Li-Bo
• Wu, Li-Jun
• Nakamura, Seikou
• Yoshikawa, Masayuki
• Matsuda, Hisashi

Titel

Dipeptidyl peptidase-IV inhibitory activity of dimeric dihydrochalcone glycosides from flowers of Helichrysum arenarium

Ist Teil von

• Journal of natural medicines, 2015-10, Vol.69 (4), p.494-506

Ort / Verlag

Tokyo: Springer Japan

Erscheinungsjahr

2015

Quelle

SpringerLink Journals

Beschreibungen/Notizen

• A methanol extract of everlasting flowers of Helichrysum arenarium L. Moench (Asteraceae) was found to inhibit the increase in blood glucose elevation in sucrose-loaded mice at 500 mg/kg p.o. The methanol extract also inhibited the enzymatic activity against dipeptidyl peptidase-IV (DPP-IV, IC 50  = 41.2 μg/ml), but did not show intestinal α -glucosidase inhibitory activities. From the extract, three new dimeric dihydrochalcone glycosides, arenariumosides V–VII ( 2 – 4 ), were isolated, and the stereostructures were elucidated based on their spectroscopic properties and chemical evidence. Of the constituents, several flavonoid constituents, including 2 – 4 , were isolated, and these isolated constituents were investigated for their DPP-IV inhibitory effects. Among them, chalconaringenin 2′- O - β -D-glucopyranoside ( 16 , IC 50  = 23.1 μM) and aureusidin 6- O - β -D-glucopyranoside ( 35 , 24.3 μM) showed relatively strong inhibitory activities.