Acta biochimica et biophysica Sinica, 2016-01, Vol.48 (1), p.82-89
2016
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- Autor(en) / Beteiligte
- Titel
- Multifaceted roles for thymine DNA glycosylase in embryonic development and human carcinogenesis
- Ist Teil von
- Acta biochimica et biophysica Sinica, 2016-01, Vol.48 (1), p.82-89
- Ort / Verlag
- China: Oxford University Press
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Thymine DNA glycosylase （TDG） is a multifunctional protein that plays important roles in DNA repair, DNA demethylation, and transcriptional regulation. These diverse functions make TDG a unique enzyme in embryonic development and carcinogenesis. This review discusses the molecular function of TDG in human cancers and the previously unrecognized value of TDG as a potential target for drug therapy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1672-9145eISSN: 1745-7270DOI: 10.1093/abbs/gmv083Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4689155
- Format
- –
- Schlagworte
- Animals, Carcinogenesis, DNA - genetics, DNA Methylation, DNA Repair, DNA修复, DNA甲基化, Gene Expression Regulation, Developmental, Gene Expression Regulation, Neoplastic, Humans, Mice, Mutation, Neoplasms - genetics, Neoplasms - metabolism, Protein Processing, Post-Translational, Reviews, Substrate Specificity, Thymine DNA Glycosylase - metabolism, 功能蛋白, 糖基化, 肿瘤发生, 胚胎发育, 胸腺嘧啶, 酶