Details

Autor(en) / Beteiligte

• Peterson, Courtney M.
• Lecoultre, Virgile
• Frost, Elizabeth A.
• Simmons, Jonathan
• Redman, Leanne M.
• Ravussin, Eric

Titel

The thermogenic responses to overfeeding and cold are differentially regulated

Ist Teil von

• Obesity (Silver Spring, Md.), 2016-01, Vol.24 (1), p.96-101

Ort / Verlag

United States: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• Objective Brown adipose tissue (BAT) is a highly metabolic tissue that generates heat and is negatively associated with obesity. BAT has been proposed to mediate both cold‐induced thermogenesis (CIT) and diet‐induced thermogenesis (DIT). Therefore, it was investigated whether there is a relationship between CIT and DIT in humans. Methods Nine healthy men (23 ± 3 years old, 23.0 ± 1.8 kg m−2) completed 20 min of cold exposure (4°C) 5 days per week for 4 weeks. Before and after the intervention, CIT (the increase in resting metabolic rate at 16°C relative to 22°C) was measured by a ventilated hood indirect calorimeter, whereas DIT was measured as the 24‐h thermic response to 1 day of 50% overfeeding (TEF150%) in a respiratory chamber. Results After the cold intervention, CIT more than doubled from 5.2% ± 14.2% at baseline to 12.0% ± 11.1% (P = 0.05), in parallel with increased sympathetic nervous system activity. However, 24‐h energy expenditure (2,166 ± 206 vs. 2,118 ± 188 kcal day−1; P = 0.15) and TEF150% (7.4% ± 2.7% vs. 7.7% ± 1.6%; P = 0.78) were unchanged. Moreover, there was no association between CIT and TEF150% at baseline or post‐intervention, nor in their changes (P ≥ 0.47). Conclusions Cold acclimation resulted in increased CIT but not TEF150%. Therefore, it is likely that CIT and DIT are mediated by distinct regulatory mechanisms.