Details

Autor(en) / Beteiligte

• Liu, Runhui
• Chen, Xinyu
• Falk, Shaun P
• Masters, Kristyn S
• Weisblum, Bernard
• Gellman, Samuel H

Titel

Nylon‑3 Polymers Active against Drug-Resistant Candida albicans Biofilms

Ist Teil von

• Journal of the American Chemical Society, 2015-02, Vol.137 (6), p.2183-2186

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Candida albicans is the most common fungal pathogen in humans, and most diseases produced by C. albicans are associated with biofilms. We previously developed nylon-3 polymers with potent activity against planktonic C. albicans and excellent C. albicans versus mammalian cell selectivity. Here we show that these nylon-3 polymers have strong and selective activity against drug-resistant C. albicans in biofilms, as manifested by inhibition of biofilm formation and by killing of C. albicans in mature biofilms. The best nylon-3 polymer (poly-βNM) is superior to the antifungal drug fluconazole for all three strains examined. This polymer is slightly less effective than amphotericin B (AmpB) for two strains, but the polymer is superior against an AmpB-resistant strain.