Details

Autor(en) / Beteiligte

• Barnett, Brian
• Gokhale, Runa H.
• Krysiak, Robert
• Kanyemba, Creto
• Chikaonda, Tarsizio
• Bokosi, Mphatso
• Mukuzunga, Cornelius
• Saidi, Friday
• Phiri, Sam
• Hoffman, Irving F.
• Hosseinipour, Mina C.

Titel

Prevalence of drug resistant TB among outpatients at an HIV/TB clinic in Lilongwe, Malawi

Ist Teil von

• Transactions of the Royal Society of Tropical Medicine and Hygiene, 2015-12, Vol.109 (12), p.763-768

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2015

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Background We sought to determine the prevalence of drug resistant TB among outpatients initiating TB treatment in Lilongwe, Malawi. Methods This was a prospective cohort study of patients 18 years and older initiating TB treatment at Martin Preuss Centre, the primary integrated HIV/TB clinic in Lilongwe, Malawi, from April 2011 to July 2012. Procedures included questionnaires, physical exam, chest x-ray, full blood count and sputum collection. Sputum samples underwent acid-fast bacilli (AFB) smear testing and culture by Lowenstein-Jensen (LJ) and liquid Mycobacteria Growth Indicator Tube (MGIT) methods. Drug sensitivity was investigated using the Hain GenoType MTBDRplus line probe assay. Results Of the 702 patients, 219 (31.2%) were female and 653 (93.0%) were presenting for first-time TB treatment. HIV co-infection was present in 420 (59.8%) cases, with 137 (32.6%) of those patients receiving antiretroviral therapy at presentation. TB was culture-confirmed in 375 (53.4%) patients, 349 of which were first time treatment and 26 retreatment. Ten cases of isoniazid-resistant TB (2.9% of culture confirmed cases of newly treated TB), one of rifampin-resistant TB (0.3% culture confirmed cases of newly treated TB) and one of multi-drug resistant TB (MDR-TB) (3.8% of culture confirmed cases of retreatment TB) were detected. Conclusions MDR-TB prevalence is low among outpatients initiating TB treatment in Lilongwe.