Antimicrobial agents and chemotherapy, 2015-12, Vol.59 (12), p.7823-7825
2015
Details
- Autor(en) / Beteiligte
- Titel
- Microbiological Assessment of Polymyxin B Components Tested Alone and in Combination
- Ist Teil von
- Antimicrobial agents and chemotherapy, 2015-12, Vol.59 (12), p.7823-7825
- Ort / Verlag
- United States: American Society for Microbiology
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
- Beschreibungen/Notizen
- We investigated the antimicrobial activity of four polymyxin B components, B1, B2, B3, and isoleucine (Ile)-B1, individually and in combination. B3 was the most active agent against all organisms tested except Acinetobacter baumannii, for which Ile-B1 was most active. One combination met the criteria for synergy, B3 plus Ile-B1. No combinations exhibited antagonism. The dominant components of polymyxin B products (B1 and B2) were associated with the lowest probability of improved antibacterial activity when combined.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0066-4804eISSN: 1098-6596DOI: 10.1128/AAC.01021-15Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4649206
- Format
- –
- Schlagworte
- Acinetobacter baumannii, Acinetobacter baumannii - drug effects, Acinetobacter baumannii - growth & development, Anti-Bacterial Agents, Anti-Bacterial Agents - pharmacology, Caprylates, Caprylates - chemistry, Drug Synergism, Escherichia coli - drug effects, Escherichia coli - growth & development, Klebsiella pneumoniae - drug effects, Klebsiella pneumoniae - growth & development, Microbial Sensitivity Tests, Pharmacology, Polymyxin B, Polymyxin B - analogs & derivatives, Polymyxin B - chemistry, Polymyxin B - pharmacology, Pseudomonas aeruginosa - drug effects, Pseudomonas aeruginosa - growth & development, Structure-Activity Relationship