Biopolymers, 2010, Vol.94 (4), p.385-396
2010
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Details
- Autor(en) / Beteiligte
- Titel
- Sortase transpeptidases: Insights into mechanism, substrate specificity, and inhibition
- Ist Teil von
- Biopolymers, 2010, Vol.94 (4), p.385-396
- Ort / Verlag
- Hoboken: Wiley Subscription Services, Inc., A Wiley Company
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Gram‐positive bacteria pose a serious healthcare threat. The growing antibiotic resistance epidemic creates a dire need for new antibiotic targets. The sortase family of enzymes is a promising target for antimicrobial therapy. This review covers the current knowledge of the mechanism, substrate specificity, and inhibitory studies of the Gram‐positive bacter a enzyme sortase. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 385–396, 2010.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-3525eISSN: 1097-0282DOI: 10.1002/bip.21472Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4648256
- Format
- –
- Schlagworte
- Aminoacyltransferases - antagonists & inhibitors, Aminoacyltransferases - chemistry, Aminoacyltransferases - metabolism, Anti-Bacterial Agents - pharmacology, Bacterial Proteins - antagonists & inhibitors, Bacterial Proteins - chemistry, Bacterial Proteins - metabolism, Cysteine Endopeptidases - chemistry, Cysteine Endopeptidases - metabolism, Drug Resistance, Bacterial - drug effects, Drug Resistance, Bacterial - physiology, Enzyme Inhibitors - chemistry, Enzyme Inhibitors - pharmacology, enzyme structure, Gram-Positive Bacteria - enzymology, sortase, substrate specificity, Substrate Specificity - drug effects, Substrate Specificity - physiology, transpeptidase, virulence factor