Details

Autor(en) / Beteiligte

• Sun, Xiao-xiao
• Yu, Qiang

Titel

Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment

Ist Teil von

• Acta pharmacologica Sinica, 2015-10, Vol.36 (10), p.1219-1227

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Recent studies have revealed extensive genetic and non-genetic variation across different geographical regions of a tumor or throughout different stages of tumor progression, which is referred to as intra-tumor heterogeneity. Several causes contribute to this phenomenon, including genomic instability, epigenetic alteration, plastic gene expression, signal transduction, and microenvironmental differences. These variables may affect key signaling pathways that regulate cancer cell growth, drive phenotypic diversity, and pose challenges to cancer treatment. Understanding the mechanisms underlying this heterogeneity will support the development of effective therapeutic strategies.