Details

Autor(en) / Beteiligte

• Li, Mingsen
• Zhou, Xingyu
• Chen, Yaosheng
• Nie, Yaping
• Huang, Huaxing
• Chen, Hu
• Mo, Delin

Titel

Not all the number of skeletal muscle fibers is determined prenatally

Ist Teil von

• BMC developmental biology, 2015-11, Vol.15 (42), p.42-42, Article 42

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The investigation of skeletal muscle development is of importance in stock farming and biomedicine. It is still ambiguous that whether animals are born with the full set of skeletal muscle fibers or if the number of myofibers continues to increase postnatally. Here, an inducible lineage-tracing system was employed to monitor the changes of myofiber number in various skeletal muscles during development. We confirm that the total myofiber number of longissimus dorsi, gastrocnemius and rectus femoris is determined prenatally. However, tibialis anterior and extensor digitorum longus have a different development pattern, and their myofiber number still increases in the first postnatal week and then remains stable afterwards. Our results highlight different development time frames of anatomically distinct skeletal muscles.