Neuroscience, 2015-12, Vol.310, p.206-215
2015
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- Autor(en) / Beteiligte
- Titel
- The role of TRPA1 in muscle pain and mechanical hypersensitivity under inflammatory conditions in rats
- Ist Teil von
- Neuroscience, 2015-12, Vol.310, p.206-215
- Ort / Verlag
- United States: Elsevier Ltd
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • TRPA1 mediates acute muscle mechanical hypersensitivity induced by ATP and glutamate. • TRPA1 contributes to the maintenance of mechanical hypersensitivity under a myositis condition. • TRPA1 contributes to the maintenance of spontaneous muscle pain under a myositis condition. • Inflammation in the masseter muscle significantly up-regulates TRPA1 expression in trigeminal ganglia.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4522eISSN: 1873-7544DOI: 10.1016/j.neuroscience.2015.09.042Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4633371
- Format
- –
- Schlagworte
- Adenosine Triphosphate - analogs & derivatives, Adenosine Triphosphate - pharmacology, Animals, AP18, craniofacial, Disease Models, Animal, Excitatory Amino Acid Agonists - toxicity, Freund's Adjuvant - adverse effects, Hyperalgesia - chemically induced, Hyperalgesia - pathology, Male, muscle afferents, Myalgia - etiology, Myalgia - pathology, myositis, Myositis - complications, N-Methylaspartate - toxicity, Neurology, Oximes - toxicity, Pain Threshold - drug effects, Pain Threshold - physiology, Rats, Rats, Sprague-Dawley, trigeminal ganglia, Trigeminal Ganglion - metabolism, TRPA1 Cation Channel, TRPC Cation Channels - antagonists & inhibitors, TRPC Cation Channels - metabolism, Up-Regulation - drug effects, Up-Regulation - ethics