Neuroscience, 2015-12, Vol.310, p.541-548
2015
Details
- Autor(en) / Beteiligte
- Titel
- Phoenixin: A candidate pruritogen in the mouse
- Ist Teil von
- Neuroscience, 2015-12, Vol.310, p.541-548
- Ort / Verlag
- United States: Elsevier Ltd
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Phoenixin (PNX), a novel peptide of 14 amino acids, is detected in the mouse spinal cord. • PNX is expressed in DRGs with axons projecting to the dorsal horn and peripherally to the skin. • PNX upon subcutaneous injection to the nape of the neck of mice provokes scratching behavior. • PNX-induced scratching is attenuated by nalfurafine, the kappa opioid receptor agonist. • PNX is one of the endogenous signaling molecules involved in itch transmission in the mouse.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4522eISSN: 1873-7544DOI: 10.1016/j.neuroscience.2015.09.055Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4633352
- Format
- –
- Schlagworte
- Amino Acids - chemistry, Animals, Behavior, Animal - drug effects, Cervical Cord - metabolism, dorsal root ganglion, Ganglia, Spinal - metabolism, itch, kappa opioid receptor, Male, Mice, nalfurafine, Neck - innervation, Neurology, Peptides - chemistry, Peptides - metabolism, Peptides - pharmacology, Peptides - physiology, primary afferent neuron, pruritogen, Pruritus - chemically induced, Skin - metabolism, Spinal Cord - metabolism