Details

Autor(en) / Beteiligte

• Pfeifer, Philipp
• Jansen, Felix
• Werner, Nikos
• Han, Renzhi

Titel

Role and Function of MicroRNAs in Extracellular Vesicles in Cardiovascular Biology

Ist Teil von

• BioMed research international, 2015-01, Vol.2015 (2015), p.1-11

Ort / Verlag

Cairo, Egypt: Hindawi Publishing Corporation

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Intercellular communication mediated by extracellular vesicles is crucial for preserving vascular integrity and in the development of cardiovascular disease. Extracellular vesicles consist of apoptotic bodies, microvesicles, and exosomes that can be found in almost every fluid compartment of the body like blood, saliva, and urine. In the recent years, a lot of reports came up suggesting that major cardiovascular and metabolic pathologies like atherogenesis, heart failure, or diabetes are highly influenced by transfer of microRNAs via extracellular vesicles leading to altered protein expression and phenotypes of recipient cells. The following review will summarize the fast developing field of intercellular signaling in cardiovascular biology by microRNA-containing extracellular vesicles.