Details

Autor(en) / Beteiligte

• Pak, Theodore R
• Altman, Deena R
• Attie, Oliver
• Sebra, Robert
• Hamula, Camille L
• Lewis, Martha
• Deikus, Gintaras
• Newman, Leah C
• Fang, Gang
• Hand, Jonathan
• Patel, Gopi
• Wallach, Fran
• Schadt, Eric E
• Huprikar, Shirish
• van Bakel, Harm
• Kasarskis, Andrew
• Bashir, Ali

Titel

Whole-genome sequencing identifies emergence of a quinolone resistance mutation in a case of Stenotrophomonas maltophilia bacteremia

Ist Teil von

• Antimicrobial agents and chemotherapy, 2015-11, Vol.59 (11), p.7117-7120

Ort / Verlag

United States: American Society for Microbiology

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Whole-genome sequences for Stenotrophomonas maltophilia serial isolates from a bacteremic patient before and after development of levofloxacin resistance were assembled de novo and differed by one single-nucleotide variant in smeT, a repressor for multidrug efflux operon smeDEF. Along with sequenced isolates from five contemporaneous cases, they displayed considerable diversity compared against all published complete genomes. Whole-genome sequencing and complete assembly can conclusively identify resistance mechanisms emerging in S. maltophilia strains during clinical therapy.