FEBS letters, 2015-10, Vol.589 (20), p.2923-2930
2015
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Details
- Autor(en) / Beteiligte
- Titel
- Architectural proteins, transcription, and the three-dimensional organization of the genome
- Ist Teil von
- FEBS letters, 2015-10, Vol.589 (20), p.2923-2930
- Ort / Verlag
- England: Elsevier B.V
- Erscheinungsjahr
- 2015
- Quelle
- Wiley-Blackwell Journals
- Beschreibungen/Notizen
- Architectural proteins mediate interactions between distant sequences in the genome. Two well-characterized functions of architectural protein interactions include the tethering of enhancers to promoters and bringing together Polycomb-containing sites to facilitate silencing. The nature of which sequences interact genome-wide appears to be determined by the orientation of the architectural protein binding sites as well as the number and identity of architectural proteins present. Ultimately, long range chromatin interactions result in the formation of loops within the chromatin fiber. In this review, we discuss data suggesting that architectural proteins mediate long range chromatin interactions that both facilitate and hinder neighboring interactions, compartmentalizing the genome into regions of highly interacting chromatin domains.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1016/j.febslet.2015.05.025Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4598269
- Format
- –
- Schlagworte
- Animals, Binding Sites, CCCTC-binding factor, ChIA-PET, ChIP-seq, Chromatin, Chromatin - physiology, Chromatin - ultrastructure, chromatin immunoprecipitation-sequencing, chromatin interaction analysis by paired-end tag sequencing, chromosome conformation capture, DNA-Binding Proteins - physiology, Epigenesis, Genetic, Epigenetics, Genome, Human, Humans, Insulator, Nucleic Acid Conformation, Protein Binding, Regulatory Sequences, Nucleic Acid, self-transcribing active regulatory region sequencing, STARR-seq, Topologically associating domain, Transcription, Genetic