Details

Autor(en) / Beteiligte

• Vargas, H. A.
• Burger, I. A.
• Goldman, D. A.
• Miccò, M.
• Sosa, R. E.
• Weber, W.
• Chi, D. S.
• Hricak, H.
• Sala, E.

Titel

Volume-based quantitative FDG PET/CT metrics and their association with optimal debulking and progression-free survival in patients with recurrent ovarian cancer undergoing secondary cytoreductive surgery

Ist Teil von

• European radiology, 2015-11, Vol.25 (11), p.3348-3353

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective Our aim was to evaluate the associations between quantitative 18  F-fluorodeoxyglucose positron-emission tomography (FDG-PET) uptake metrics, optimal debulking (OD) and progression-free survival (PFS) in patients with recurrent ovarian cancer undergoing secondary cytoreductive surgery. Methods Fifty-five patients with recurrent ovarian cancer underwent FDG-PET/CT within 90 days prior to surgery. Standardized uptake values (SUV max ), metabolically active tumour volumes (MTV), and total lesion glycolysis (TLG) were measured on PET. Exact logistic regression, Kaplan-Meier curves and the log-rank test were used to assess associations between imaging metrics, OD and PFS. Results MTV ( p  = 0.0025) and TLG ( p  = 0.0043) were associated with OD; however, there was no significant association between SUV max and debulking status ( p  = 0.83). Patients with an MTV above 7.52 mL and/or a TLG above 35.94 g had significantly shorter PFS ( p  = 0.0191 for MTV and p  = 0.0069 for TLG). SUV max was not significantly related to PFS ( p  = 0.10). PFS estimates at 3.5 years after surgery were 0.42 for patients with an MTV ≤ 7.52 mL and 0.19 for patients with an MTV > 7.52 mL; 0.46 for patients with a TLG ≤ 35.94 g and 0.15 for patients with a TLG > 35.94 g. Conclusion FDG-PET metrics that reflect metabolic tumour burden are associated with optimal secondary cytoreductive surgery and progression-free survival in patients with recurrent ovarian cancer. Key Points • Both TLG and MTV were associated with optimal tumour debulking. • There was no significant association between SUV max and tumour debulking status. • Patients with higher MTV and/or TLG had significantly shorter PFS. • SUV max was not significantly related to PFS.