Details

Autor(en) / Beteiligte

• Benham-Pyle, Blair W.
• Pruitt, Beth L.
• Nelson, W. James

Titel

Mechanical strain induces E-cadherin-dependent Yap1 and β-catenin activation to drive cell cycle entry

Ist Teil von

• Science (American Association for the Advancement of Science), 2015-05, Vol.348 (6238), p.1024-1027

Ort / Verlag

American Association for the Advancement of Science

Erscheinungsjahr

2015

Link zum Volltext

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• Mechanical strain regulates the development organization, and function of multicellular tissues, but mechanisms linking mechanical strain and cell-cell junction proteins to cellular responses are poorly understood. Here, we showed that mechanical strain applied to quiescent epithelial cells induced rapid cell cycle reentry, mediated by independent nuclear accumulation and transcriptional activity of first Yap1 and then β-catenin. Inhibition of Yap1- and β-catenin-mediated transcription blocked cell cycle reentry and progression through G₁ into S phase, respectively. Maintenance of quiescence, Yap1 nuclear exclusion, and β-catenin transcriptional responses to mechanical strain required E-cadherin extracellular engagement. Thus, activation of Yap1 and β-catenin may represent a master regulator of mechanical strain-induced cell proliferation, and cadherins provide signaling centers required for cellular responses to externally applied force.