Details

Autor(en) / Beteiligte

• Ussar, Siegfried
• Griffin, Nicholas W.
• Bezy, Olivier
• Fujisaka, Shiho
• Vienberg, Sara
• Softic, Samir
• Deng, Luxue
• Bry, Lynn
• Gordon, Jeffrey I.
• Kahn, C. Ronald

Titel

Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome

Ist Teil von

• Cell metabolism, 2015-09, Vol.22 (3), p.516-530

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Obesity, diabetes, and metabolic syndrome result from complex interactions between genetic and environmental factors, including the gut microbiota. To dissect these interactions, we utilized three commonly used inbred strains of mice—obesity/diabetes-prone C57Bl/6J mice, obesity/diabetes-resistant 129S1/SvImJ from Jackson Laboratory, and obesity-prone but diabetes-resistant 129S6/SvEvTac from Taconic—plus three derivative lines generated by breeding these strains in a new, common environment. Analysis of metabolic parameters and gut microbiota in all strains and their environmentally normalized derivatives revealed strong interactions between microbiota, diet, breeding site, and metabolic phenotype. Strain-dependent and strain-independent correlations were found between specific microbiota and phenotypes, some of which could be transferred to germ-free recipient animals by fecal transplantation. Environmental reprogramming of microbiota resulted in 129S6/SvEvTac becoming obesity resistant. Thus, development of obesity/metabolic syndrome is the result of interactions between gut microbiota, host genetics, and diet. In permissive genetic backgrounds, environmental reprograming of microbiota can ameliorate development of metabolic syndrome. [Display omitted] •Host genetics determine changes in gut microbiota in response to high-fat diet•Environmental history impacts on gut microbiota and response to dietary challenges•Specific bacterial taxa correlate with metabolic phenotypes within and across strains•Diet, host genetics, and gut microbiota interact in development of metabolic syndrome In a longitudinal analysis of host genetics, diet, and gut microbiota interations, Ussar et al. demonstrate how interactions between the gut microbiota, host genetics, and diet influence the development of metabolic syndrome. The authors find that specific bacterial taxa appear to be linked to specific phenotypes. Changing the environment in early life not only changes the microbiota but also changes development of metabolic syndrome.