Details

Autor(en) / Beteiligte

• Lundgren, Jens D
• Babiker, Abdel G
• Gordin, Fred
• Emery, Sean
• Grund, Birgit
• Sharma, Shweta
• Avihingsanon, Anchalee
• Cooper, David A
• Fätkenheuer, Gerd
• Llibre, Josep M
• Molina, Jean-Michel
• Munderi, Paula
• Schechter, Mauro
• Wood, Robin
• Klingman, Karin L
• Collins, Simon
• Lane, H Clifford
• Phillips, Andrew N
• Neaton, James D

Titel

Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection

Ist Teil von

• The New England journal of medicine, 2015-08, Vol.373 (9), p.795-807

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• When to start antiretroviral therapy for HIV infection on the basis of the CD4+ count has been controversial. In a global randomized trial, treatment of patients with a CD4+ count of more than 500 cells per cubic millimeter showed significant benefit. The immune compromise caused by the human immunodeficiency virus (HIV) is characterized by a loss of CD4+ T cells. Rates of HIV-associated complications and death increase as the number of these cells in peripheral blood (CD4+ count) declines. 1 – 3 It has been general practice to defer the initiation of antiretroviral therapy in asymptomatic patients with a CD4+ count above a certain threshold level. The applicable threshold has changed over time, and recommendations remain inconsistent across various guidelines. 4 Randomized studies that have assessed the benefits and risks of treating patients with HIV infection sooner rather than later have largely enrolled patients . . .