Details

Autor(en) / Beteiligte

• Turan, Nedim
• Benekli, Mustafa
• Unal, Olcun Umit
• Unek, İlkay Tugba
• Tastekin, Didem
• Dane, Faysal
• Algın, Efnan
• Ulger, Sukran
• Eren, Tulay
• Topcu, Turkan Ozturk
• Turkmen, Esma
• Babacan, Nalan Akgül
• Tufan, Gulnihal
• Urakci, Zuhat
• Ustaalioglu, Basak Oven
• Uysal, Ozlem Sonmez
• Ercelep, Ozlem Balvan
• Taskoylu, Burcu Yapar
• Aksoy, Asude
• Canhoroz, Mustafa
• Demirci, Umut
• Dogan, Erkan
• Berk, Veli
• Balakan, Ozan
• Ekinci, Ahmet Şiyar
• Uysal, Mukremin
• Petekkaya, İbrahim
• Ozturk, Selçuk Cemil
• Tonyalı, Önder
• Çetin, Bülent
• Aldemir, Mehmet Naci
• Helvacı, Kaan
• Ozdemir, Nuriye
• Oztop, İlhan
• Coskun, Ugur
• Uner, Aytug
• Ozet, Ahmet
• Buyukberber, Suleyman

Titel

Impact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma

Ist Teil von

• Chinese journal of cancer research, 2015-08, Vol.27 (4), p.408-416

Ort / Verlag

China: Department of Medical Oncology, Faculty of Medicine, Cumhuriyet University, Sivas 58140, Turkey%Department of Medical Oncology, Faculty of Medicine, Gazi University, Ankara 06560, Turkey%Department of Medical Oncology, Faculty of Medicine, Dokuz EylulUniversity, Izmir 35340, Turkey%Department of Medical Oncology, Faculty of Medicine, Necmettin Erbakan University, Konya 42080, Turkey%Department of Medical Oncology, Faculty of Medicine, Marmara University, Istanbul 34000, Turkey

Erscheinungsjahr

2015

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• We examined the impact of adjuvant modalities on resected pancreatic and periampullary adenocarcinoma (PAC). A total of 563 patients who were curatively resected for PAC were retrospectively analyzed between 2003 and 2013. Of 563 patients, 472 received adjuvant chemotherapy (CT) alone, chemoradiotherapy (CRT) alone, and chemoradiotherapy plus chemotherapy (CRT-CT) were analyzed. Of the 472 patients, 231 were given CRT-CT, 26 were given CRT, and 215 were given CT. The median recurrence-free survival (RFS) and overall survival (OS) were 12 and 19 months, respectively. When CT and CRT-CT groups were compared, there was no significant difference with respect to both RFS and OS, and also there was no difference in RFS and OS among CRT-CT, CT and CRT groups. To further investigate the impact of radiation on subgroups, patients were stratified according to lymph node status and resection margins. In node-positive patients, both RFS and OS were significantly longer in CRT-CT than CT. In contrast, there was no significant difference between groups when patients with node-negative disease or patients with or without positive surgical margins were considered. Addition of radiation to CT has a survival benefit in patients with node-positive disease following pancreatic resection.