Current opinion in immunology, 2015-08, Vol.35, p.30-38
2015
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Details
- Autor(en) / Beteiligte
- Titel
- Novel antigens for RSV vaccines
- Ist Teil von
- Current opinion in immunology, 2015-08, Vol.35, p.30-38
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • There are multiple neutralizing antibody binding sites on F protein and at least one on G protein. • The most potent neutralizing antibodies recognize sites exclusively on the prefusion conformation of F. • mAbs with intermediate neutralizing potency recognize two sites present on both pre-F and post-F. • F immunogens stabilized in a pre-F conformation improve prospects for an effective RSV vaccine.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0952-7915eISSN: 1879-0372DOI: 10.1016/j.coi.2015.04.005Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4553118
- Format
- –
- Schlagworte
- Allergy and Immunology, Animals, Antibodies, Neutralizing - metabolism, Epitopes, B-Lymphocyte - metabolism, Humans, Immunity, Infant, Newborn, Protein Conformation, Respiratory syncytial virus, Respiratory Syncytial Virus Infections - immunology, Respiratory Syncytial Virus Infections - prevention & control, Respiratory Syncytial Virus Vaccines - immunology, Respiratory Syncytial Viruses - immunology, Structure-Activity Relationship, Viral Fusion Proteins - immunology, Viral Fusion Proteins - metabolism