Cancer letters, 2015-10, Vol.366 (2), p.150-159
2015
Details
- Autor(en) / Beteiligte
- Titel
- The sulfiredoxin–peroxiredoxin (Srx–Prx) axis in cell signal transduction and cancer development
- Ist Teil von
- Cancer letters, 2015-10, Vol.366 (2), p.150-159
- Ort / Verlag
- Ireland: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Specificity of individual Prx signaling is determined by minor molecular changes. • Difference in Srx–individual Prx affinity is defined by their molecular differences. • All enzymatic activities of Srx/Prx collaborate to maintain cellular homeostasis. • Srx–Prx axis regulates carcinogenesis through modulation of cell-signaling pathways. • Srx–Prx axis is a promising therapeutic target in variety of human cancers.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3835eISSN: 1872-7980DOI: 10.1016/j.canlet.2015.07.002Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4532351
- Format
- –
- Schlagworte
- Animals, Antioxidants, Antioxidants - metabolism, Apoptosis, Bladder cancer, Brain research, Breast cancer, Cell Transformation, Neoplastic - metabolism, Cyanobacteria, Disease Progression, Epidermal growth factor, Esophageal cancer, Glutathione - metabolism, Head & neck cancer, Hematology, Oncology and Palliative Medicine, Homeostasis, Humans, Independent study, Kidney cancer, Kinases, Leukemia, Liver cancer, Lymphoma, Metabolism, Metabolites, Molecular Chaperones - metabolism, Multiple myeloma, Neoplasm Metastasis - physiopathology, Oncogene, Oxidation-Reduction, Oxidative stress, Oxidoreductases - metabolism, Oxidoreductases Acting on Sulfur Group Donors - metabolism, Pancreatic cancer, Peroxiredoxin, Peroxiredoxins - metabolism, Physiology, Prokaryotes, Prostate cancer, Protein folding, Redox signaling, Roles, Signal Transduction - physiology, Skin cancer, Stomach cancer, Substrate Specificity, Sulfiredoxin, Tumorigenesis