Oncology letters, 2015-08, Vol.10 (2), p.583-588
2015
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- Autor(en) / Beteiligte
- Titel
- BMI-1, a promising therapeutic target for human cancer
- Ist Teil von
- Oncology letters, 2015-08, Vol.10 (2), p.583-588
- Ort / Verlag
- Greece: D.A. Spandidos
- Erscheinungsjahr
- 2015
- Quelle
- EZB Free E-Journals
- Beschreibungen/Notizen
- BMI-1 oncogene is a member of the polycomb-group gene family and a transcriptional repressor. Overexpression of BMI-1 has been identified in various human cancer tissues and is known to be involved in cancer cell proliferation, cell invasion, distant metastasis, chemosensitivity and patient survival. Accumulating evidence has revealed that BMI-1 is also involved in the regulation of self-renewal, differentiation and tumor initiation of cancer stem cells (CSCs). However, the molecular mechanisms underlying these biological processes remain unclear. The present review summarized the function of BMI-1 in different human cancer types and CSCs, and discussed the signaling pathways in which BMI-1 is potentially involved. In conclusion, BMI-1 may represent a promising target for the prevention and therapy of various cancer types.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1792-1074eISSN: 1792-1082DOI: 10.3892/ol.2015.3361Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4509079
- Format
- –
- Schlagworte
- Angiogenesis, Apoptosis, BMI-1, Brain cancer, Breast cancer, Cancer, cancer stem cells, Cancer therapies, Care and treatment, Cell cycle, Cell growth, Drug resistance, Gastric cancer, Head & neck cancer, Hematology, human cancer, Leukemia, Liver cancer, Lung cancer, Lymphoma, Medical prognosis, Metastasis, Motility, Oncogenes, Oncology, Oncology, Experimental, Ovarian cancer, Pancreatic cancer, Patients, poor prognosis, Review, Skin cancer, Stem cells, Studies, therapeutic target, Tumors