Advanced drug delivery reviews, 2015-06, Vol.87, p.3-14
2015
Details
- Autor(en) / Beteiligte
- Titel
- An overview of microRNAs
- Ist Teil von
- Advanced drug delivery reviews, 2015-06, Vol.87, p.3-14
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The discovery of the first microRNA (miRNA) over 20years ago has ushered in a new era in molecular biology. There are now over 2000 miRNAs that have been discovered in humans and it is believed that they collectively regulate one third of the genes in the genome. miRNAs have been linked to many human diseases and are being pursued as clinical diagnostics and as therapeutic targets. This review presents an overview of the miRNA pathway, including biogenesis routes, biological roles, and clinical approaches. [Display omitted]
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0169-409XeISSN: 1872-8294DOI: 10.1016/j.addr.2015.05.001Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4504744
- Format
- –
- Schlagworte
- Animals, Argonaute, Dicer, Drosha, Drug Discovery, Humans, Metabolic Diseases - genetics, Metabolic Diseases - therapy, MicroRNA, MicroRNAs - antagonists & inhibitors, MicroRNAs - biosynthesis, MicroRNAs - genetics, miRNA, Molecular Targeted Therapy, Neoplasms - genetics, Neoplasms - therapy, Oligonucleotides, Antisense - administration & dosage, Oligonucleotides, Antisense - therapeutic use, Ribonuclease III - genetics, Ribonuclease III - metabolism, RNA Interference, RNAi