Details

Autor(en) / Beteiligte

• Wu, Xiaoqiu
• Zhao, Zilong
• Bai, Huarong
• Fu, Ting
• Yang, Chao
• Hu, Xiaoxiao
• Liu, Qiaoling
• Champanhac, Carole
• Teng, I-Ting
• Ye, Mao
• Tan, Weihong

Titel

DNA Aptamer Selected against Pancreatic Ductal Adenocarcinoma for in vivo Imaging and Clinical Tissue Recognition

Ist Teil von

• Theranostics, 2015-01, Vol.5 (9), p.985-994

Ort / Verlag

Australia: Ivyspring International Publisher

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• In this work, we have developed a truncated DNA aptamer, termed XQ-2d, with high affinity and specificity for pancreatic ductal adenocarcinoma (PDAC). Aptamer XQ-2d selectively binds to PL45 cells with a dissociation constant in the nanomolar range, as determined by its recognition of PL45 tumor cells in mice. Moreover, XQ-2d shows better recognition ratio for 40 tissue sections of clinical PDAC samples (82.5%) compared to the initial cell-SELEX selection library (5%). Therefore, XQ-2d can be considered a promising candidate as a tool for PDAC diagnosis and treatment.