Brain, behavior, and immunity, 2015-07, Vol.47, p.131-140
2015
Details
- Autor(en) / Beteiligte
- Titel
- Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse
- Ist Teil von
- Brain, behavior, and immunity, 2015-07, Vol.47, p.131-140
- Ort / Verlag
- Netherlands: Elsevier Inc
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Diffuse TBI resulted in motor and cognitive impairments in the mouse. • AT-RvD1, but not RvE1, facilitated functional recovery. • RvE1-treated brain-injured mice slept significantly more immediately after TBI. • RvE1, but not AT-RvD1, decreased the injury-induced activation of microglia to TBI. • AT-RvD1 & RvE1 independently altered sleep, inflammation, and outcome after TBI.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0889-1591eISSN: 1090-2139DOI: 10.1016/j.bbi.2015.01.001Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4468045
- Format
- –
- Schlagworte
- Allergy and Immunology, Animals, Aspirin-triggered resolvin, Behavior, Brain Injuries - metabolism, Brain Injuries - physiopathology, Cognition - drug effects, Cognition - physiology, Docosahexaenoic Acids - pharmacology, Eicosapentaenoic Acid - analogs & derivatives, Eicosapentaenoic Acid - pharmacology, Inflammation, Inflammation - metabolism, Inflammation - physiopathology, Male, Memory - drug effects, Memory - physiology, Mice, Mice, Inbred C57BL, Microglia - drug effects, Microglia - metabolism, Motor Activity - drug effects, Motor Activity - physiology, Mouse, Protectins, Psychiatry, Resolvins, Sleep, Sleep - drug effects, Sleep - physiology, TBI