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MicroRNAome genome: A treasure for cancer diagnosis and therapy
CA: a cancer journal for clinicians, 2014-09, Vol.64 (5), p.311-336
Berindan‐Neagoe, Ioana
Monroig, Paloma del C.
Pasculli, Barbara
Calin, George A.
2014
Details
Autor(en) / Beteiligte
Berindan‐Neagoe, Ioana
Monroig, Paloma del C.
Pasculli, Barbara
Calin, George A.
Titel
MicroRNAome genome: A treasure for cancer diagnosis and therapy
Ist Teil von
CA: a cancer journal for clinicians, 2014-09, Vol.64 (5), p.311-336
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2014
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
The interplay between abnormalities in genes coding for proteins and noncoding microRNAs (miRNAs) has been among the most exciting yet unexpected discoveries in oncology over the last decade. The complexity of this network has redefined cancer research as miRNAs, produced from what was once considered “genomic trash,” have shown to be crucial for cancer initiation, progression, and dissemination. Naturally occurring miRNAs are very short transcripts that never produce a protein or amino acid chain, but act by regulating protein expression during cellular processes such as growth, development, and differentiation at the transcriptional, posttranscriptional, and/or translational level. In this review article, miRNAs are presented as ubiquitous players involved in all cancer hallmarks. The authors also describe the most used methods to detect their expression, which have revealed the identity of hundreds of miRNAs dysregulated in cancer cells or tumor microenvironment cells. Furthermore, the role of miRNAs as hormones and as reliable cancer biomarkers and predictors of treatment response is discussed. Along with this, the authors explore current strategies in designing miRNA‐targeting therapeutics, as well as the associated challenges that research envisions to overcome. Finally, a new wave in molecular oncology translational research is introduced: the study of long noncoding RNAs. CA Cancer J Clin 2014;64:311–336. © 2014 American Cancer Society.
Sprache
Englisch
Identifikatoren
ISSN: 0007-9235
eISSN: 1542-4863
DOI: 10.3322/caac.21244
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4461198
Format
–
Schlagworte
Biomarkers
,
Biomarkers, Tumor - analysis
,
Biomarkers, Tumor - genetics
,
Cancer
,
diagnosis
,
Gene Expression Regulation, Neoplastic
,
Genes
,
Genome
,
Humans
,
Medical treatment
,
microRNA
,
MicroRNAs - analysis
,
MicroRNAs - physiology
,
MicroRNAs - therapeutic use
,
Mutation
,
Neoplasms - diagnosis
,
Neoplasms - genetics
,
Neoplasms - therapy
,
Oncology
,
Protein expression
,
Ribonucleic acid
,
RNA
,
therapy
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