Circulation research, 2015-06, Vol.116 (12), p.1937-1955
2015
Details
- Autor(en) / Beteiligte
- Titel
- Mechanisms of Sudden Cardiac Death: Oxidants and Metabolism
- Ist Teil von
- Circulation research, 2015-06, Vol.116 (12), p.1937-1955
- Ort / Verlag
- United States: American Heart Association, Inc
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
- Beschreibungen/Notizen
- Ventricular arrhythmia is the leading cause of sudden cardiac death (SCD). Deranged cardiac metabolism and abnormal redox state during cardiac diseases foment arrhythmogenic substrates through direct or indirect modulation of cardiac ion channel/transporter function. This review presents current evidence on the mechanisms linking metabolic derangement and excessive oxidative stress to ion channel/transporter dysfunction that predisposes to ventricular arrhythmias and SCD. Because conventional antiarrhythmic agents aiming at ion channels have proven challenging to use, targeting arrhythmogenic metabolic changes and redox imbalance may provide novel therapeutics to treat or prevent life-threatening arrhythmias and SCD.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0009-7330eISSN: 1524-4571DOI: 10.1161/CIRCRESAHA.116.304691Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4458707
- Format
- –
- Schlagworte
- Arrhythmias, Cardiac - drug therapy, Arrhythmias, Cardiac - etiology, Arrhythmias, Cardiac - metabolism, Calcium Signaling, Cardiovascular Agents - pharmacology, Cardiovascular Agents - therapeutic use, Death, Sudden, Cardiac - etiology, Death, Sudden, Cardiac - prevention & control, Gap Junctions - physiology, Heart Conduction System - physiopathology, Heart Diseases - metabolism, Homeostasis, Humans, Ion Channel Gating - drug effects, Ion Channel Gating - physiology, Ion Channels - drug effects, Ion Channels - physiology, Membrane Potentials, Metabolic Diseases - complications, Metabolic Diseases - physiopathology, Mitochondria, Heart - metabolism, Myocardium - metabolism, Oxidation-Reduction, Oxidative Stress, Potassium - physiology, Reactive Oxygen Species, Sodium - physiology