Details

Autor(en) / Beteiligte

• Rodríguez-Cotto, Rosa I.
• Ortiz-Martínez, Mario G.
• Rivera-Ramírez, Evasomary
• Mateus, Vinicius L.
• Amaral, Beatriz S.
• Jiménez-Vélez, Braulio D.
• Gioda, Adriana

Titel

Particle pollution in Rio de Janeiro, Brazil: Increase and decrease of pro-inflammatory cytokines IL-6 and IL-8 in human lung cells

Ist Teil von

• Environmental pollution (1987), 2014-11, Vol.194, p.112-120

Ort / Verlag

Kidlington: Elsevier Ltd

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Particle pollution from urban and industrialized regions in Rio de Janeiro (RJ), Brazil was analyzed for toxic and pro-inflammatory (cytokines: IL-6, IL-8, IL-10) responses in human bronchial epithelial cells. Trace elements contribution was studied. Airborne particulate matter was collected at: three industrial sites Ind-1 (PM10) and Ind-2a and 2b (PM2.5); Centro urban area (PM10) and two rural sites (PM2.5, PM10). PM10 acetone extracts were toxic and did not elicit cytokine release; aqueous extracts were less toxic and stimulated the release of IL-6 and IL-8. PM2.5 aqueous extracts from Ind-2 decreased the release of IL-6 and IL-8. Zinc concentration was higher at the industrial and rural reference sites (Ref-1-2) although metals were not associated to cytokines changes. These results demonstrate that PM from RJ can either increase or decrease cytokine secretion in vitro while being site specific and time dependent. •Rio de Janeiro Industrial 2 PM2.5 extracts decreased IL-6 and IL-8 secretion.•Rio de Janeiro Industrial 1 PM10 extracts increased IL-6 and IL-8 secretion.•PM10 acetone extracts from Rio de Janeiro were very toxic to lung cells BEAS-2B.•Heavy metals were higher at the Industrial site (Ind) 1 compared to the Ind 2.•Heavy metals were not responsible for the decrease in IL-6 and IL-8 levels. PM10 increased and PM2.5 decreased IL-6 and IL-8 while metals were not associated with cytokine decrease but with cytotoxicity.