Details

Autor(en) / Beteiligte

• du Pré, B.C.
• van Veen, T.A.B.

Titel

Tackling the emperor’s wisdom: heat shock proteins to halt and reverse atrial fibrillation at its roots

Ist Teil von

• Netherlands heart journal, 2015-06, Vol.23 (6), p.321-326

Ort / Verlag

Houten: Bohn Stafleu van Loghum

Erscheinungsjahr

2015

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• [...]AF consists of heterogeneous electromechanical remodelling of the atria in a concealed phase, which is followed by presentation due to an initiating trigger. In heart failure patients with an intraventricular conduction delay, for example, cardiac resynchronisation therapy (via intervention using electrical devices) is successfully used to reverse initial cardiac remodelling caused by altered activation [4]. Curative treatment of the remodelled substrate in AF will not only support the immediate (but often short-lasting) success that cardioversion or ablation therapy have, but it also has the potential to prevent and reverse AF development, maintenance, and progression on the longer term and thereby significantly reduce the AF burden for patients and society.