Details

Autor(en) / Beteiligte

• Jenson, Hal B.
• Gauntt, Charles J.
• Easley, Kirk A.
• Pitt, Jane
• Lipshultz, Steven E.
• McIntosh, Kenneth
• Shearer, William T.

Titel

Evaluation of coxsackievirus infection in children with human immunodeficiency virus type 1-associated cardiomyopathy

Ist Teil von

• The Journal of infectious diseases, 2002-06, Vol.185 (12), p.1798-1802

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2002

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• In a matched case-control study of the association between coxsackieviruses and cardiac impairment, 24 human immunodeficiency virus (HIV) type 1-infected children with cardiac impairment were compared with 24 HIV-1-infected control subjects. Serologic evidence of coxsackievirus infection was present in all children, with no significant difference in geometric mean antibody titers between case patients and control subjects. Conditional logistic regression to test for an association between coxsackievirus antibody titer and the presence or absence of cardiac impairment, by any indicator, showed an odds ratio of 1.11 (95% confidence interval, 0.58-2.10; P = .75), indicating no association between coxsackievirus infection and cardiac impairment. Coxsackievirus antibody titers correlated positively with total IgG levels in nonrapid progressors but not in rapid progressors. Paired serum samples taken before and after diagnosis of cardiac impairment in 5 patients showed no evidence of intervening coxsackievirus infection. These results do not identify a causal role for coxsackieviruses for cardiomyopathy in HIV-1-infected children.