Free radical biology & medicine, 2013-12, Vol.65, p.371-379
2013
Details
- Autor(en) / Beteiligte
- Titel
- miR-761 regulates the mitochondrial network by targeting mitochondrial fission factor
- Ist Teil von
- Free radical biology & medicine, 2013-12, Vol.65, p.371-379
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2013
- Link zum Volltext
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Mitochondria are dynamic organelles that constantly undergo fission and fusion. The balance between fission and fusion determines the fate of the cell. In this study, we show that mitochondrial fission factor (MFF) is upregulated upon hydrogen peroxide treatment or ischemia/reperfusion (I/R) injury. Knockdown of MFF attenuated hydrogen peroxide- and I/R injury-induced cardiomyocyte apoptosis and myocardial infarction. We found that MFF is a direct target of miR-761, and miR-761 inhibits mitochondrial fission and cardiomyocyte apoptosis by repressing MFF. This study reveals a novel model of mitochondrial fission regulation, which is composed of miR-761 and MFF. Modulation of their levels may provide a new approach for tackling apoptosis and myocardial infarction.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0891-5849eISSN: 1873-4596DOI: 10.1016/j.freeradbiomed.2013.07.009Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4397917
- Format
- –
- Schlagworte
- Animals, apoptosis, Apoptosis - physiology, cardiomyocytes, hydrogen, hydrogen peroxide, Immunoblotting, Male, Mice, Mice, Inbred C57BL, MicroRNAs - metabolism, Microscopy, Electron, Transmission, mitochondria, Mitochondrial Dynamics - physiology, Mitochondrial Proteins - genetics, Mitochondrial Proteins - metabolism, myocardial infarction, Myocytes, Cardiac - metabolism, Rats, Rats, Wistar, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Transfection