Details

Autor(en) / Beteiligte

• Hedman, Andrew C
• Smith, Jessica M
• Sacks, David B

Titel

The biology of IQGAP proteins: beyond the cytoskeleton

Ist Teil von

• EMBO reports, 2015-04, Vol.16 (4), p.427-446

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and intercellular interactions. Fungal and mammalian IQGAPs are implicated in cytokinesis. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardio‐vascular system, pancreas, and lung. The functions of IQGAPs can be corrupted during oncogenesis and are usurped by microbial pathogens. Therefore, IQGAPs represent intriguing candidates for novel therapeutic agents. While modulation of the cytoskeletal architecture was initially thought to be the primary function of IQGAPs, it is now clear that they have roles beyond the cytoskeleton. This review describes contributions of IQGAPs to physiology at the organism level. IQGAP proteins regulate diverse cellular processes, including cytokinesis, migration, proliferation, and vesicle trafficking. This review discusses the roles of IQGAP proteins at the organismal level.