Details

Autor(en) / Beteiligte

• Galluzzi, Lorenzo
• Pietrocola, Federico
• Bravo-San Pedro, José Manuel
• Amaravadi, Ravi K
• Baehrecke, Eric H
• Cecconi, Francesco
• Codogno, Patrice
• Debnath, Jayanta
• Gewirtz, David A
• Karantza, Vassiliki
• Kimmelman, Alec
• Kumar, Sharad
• Levine, Beth
• Maiuri, Maria Chiara
• Martin, Seamus J
• Penninger, Josef
• Piacentini, Mauro
• Rubinsztein, David C
• Simon, Hans-Uwe
• Simonsen, Anne
• Thorburn, Andrew M
• Velasco, Guillermo
• Ryan, Kevin M
• Kroemer, Guido

Titel

Autophagy in malignant transformation and cancer progression

Ist Teil von

• The EMBO journal, 2015-04, Vol.34 (7), p.856-880

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against malignant transformation. Accordingly, many oncoproteins inhibit, and several oncosuppressor proteins promote, autophagy. Moreover, autophagy is required for optimal anticancer immunosurveillance. In neoplastic cells, however, autophagic responses constitute a means to cope with intracellular and environmental stress, thus favoring tumor progression. This implies that at least in some cases, oncogenesis proceeds along with a temporary inhibition of autophagy or a gain of molecular functions that antagonize its oncosuppressive activity. Here, we discuss the differential impact of autophagy on distinct phases of tumorigenesis and the implications of this concept for the use of autophagy modulators in cancer therapy. Autophagy has been described to have tumor‐suppressive as well as tumor‐promoting functions. This review discusses how stage and context alters the role for autophagy in cancer, and argues for further research prior to targeting autophagy in cancer therapy.