Development (Cambridge), 2003-01, Vol.130 (2), p.379-389
2003
Details
- Autor(en) / Beteiligte
- Titel
- Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation
- Ist Teil von
- Development (Cambridge), 2003-01, Vol.130 (2), p.379-389
- Ort / Verlag
- England: The Company of Biologists Limited
- Erscheinungsjahr
- 2003
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Msx2 -deficient mice exhibit progressive hair loss, starting at P14 and followed by successive cycles of wavelike regrowth and loss. During the hair cycle, Msx2 deficiency shortens anagen phase, but prolongs catagen and telogen. Msx2 -deficient hair shafts are structurally abnormal. Molecular analyses suggest a Bmp4/Bmp2/Msx2/Foxn1 acidic hair keratin pathway is involved. These structurally abnormal hairs are easily dislodged in catagen implying a precocious exogen. Deficiency in Msx2 helps to reveal the distinctive skin domains on the same mouse. Each domain cycles asynchronously â although hairs within each skin domain cycle in synchronized waves. Thus, the combinatorial defects in hair cycling and differentiation, together with concealed skin domains, account for the cyclic alopecia phenotype.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0950-1991eISSN: 1477-9129DOI: 10.1242/dev.00201Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4386654
- Format
- –
- Schlagworte
- Alopecia - pathology, Alopecia - physiopathology, Animals, Cell Differentiation - physiology, DNA-Binding Proteins - genetics, DNA-Binding Proteins - metabolism, Fibroblast Growth Factor 5, Fibroblast Growth Factors - metabolism, Forkhead Transcription Factors, Hair - growth & development, Hair - pathology, Hair - physiology, Hair Follicle - physiology, Homeodomain Proteins - genetics, Homeodomain Proteins - metabolism, In Situ Hybridization, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Biological, Phenotype, Transcription Factors - genetics, Transcription Factors - metabolism