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Minimal residual disease in myeloma by flow cytometry: independent prediction of survival benefit per log reduction
Ist Teil von
Blood, 2015-03, Vol.125 (12), p.1932-1935
Ort / Verlag
United States: Elsevier Inc
Erscheinungsjahr
2015
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
The detection of minimal residual disease (MRD) in myeloma using a 0.01% threshold (10−4) after treatment is an independent predictor of progression-free survival (PFS), but not always of overall survival (OS). However, MRD level is a continuous variable, and the predictive value of the depth of tumor depletion was evaluated in 397 patients treated intensively in the Medical Research Council Myeloma IX study. There was a significant improvement in OS for each log depletion in MRD level (median OS was 1 year for ≥10%, 4 years for 1% to <10%, 5.9 years for 0.1% to <1%, 6.8 years for 0.01% to <0.1%, and more than 7.5 years for <0.01% MRD). MRD level as a continuous variable determined by flow cytometry independently predicts both PFS and OS, with approximately 1 year median OS benefit per log depletion. The trial was registered at www.isrctn.com as #68454111.
•The level of MRD quantified by flow cytometry is more informative than a 0.01% threshold and independently predicts OS.•There was approximately 1 year survival benefit per log depletion. A lower cut point for predicting improved outcome was not reached.