Journal of dermatological science, 2015-03, Vol.77 (3), p.156-165
2015
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Details
- Autor(en) / Beteiligte
- Titel
- Gene expression profiling in pachyonychia congenita skin
- Ist Teil von
- Journal of dermatological science, 2015-03, Vol.77 (3), p.156-165
- Ort / Verlag
- Netherlands: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Both mRNA and protein profiling of PC-involved skin biopsies compared to uninvolved plantar skin identified differentially-expressed genes. • The differentially-expressed genes cluster into nine different classes according to their primary functions. • A model of the molecular pathways involved in PC pathogenesis is proposed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0923-1811eISSN: 1873-569XDOI: 10.1016/j.jdermsci.2015.01.001Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4374015
- Format
- –
- Schlagworte
- Dermatology, Desquamation, Down-Regulation, Enzymes - genetics, Gene Expression Profiling, Genodermatosis, Humans, Keratin-16 - genetics, Keratin-17 - genetics, Keratin-6 - genetics, Keratinocyte, Keratins - genetics, Monogenic skin disorder, mTOR signaling pathway, Oligonucleotide Array Sequence Analysis, Pachyonychia Congenita - complications, Pachyonychia Congenita - genetics, Pain - genetics, Painful palmoplantar keratoderma, RNA, Messenger - analysis, Transcriptome, Up-Regulation