Details

Autor(en) / Beteiligte

• Fay, André P
• Signoretti, Sabina
• Callea, Marcella
• Telό, Gabriela H
• McKay, Rana R
• Song, Jiaxi
• Carvo, Ingrid
• Lampron, Megan E
• Kaymakcalan, Marina D
• Poli-de-Figueiredo, Carlos E
• Bellmunt, Joaquim
• Hodi, F Stephen
• Freeman, Gordon J
• Elfiky, Aymen
• Choueiri, Toni K

Titel

Programmed death ligand-1 expression in adrenocortical carcinoma: an exploratory biomarker study

Ist Teil von

• Journal for immunotherapy of cancer, 2015-02, Vol.3 (1), p.3-3, Article 3

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2015

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Adrenocortical carcinoma (ACC) is a rare tumor in which prognostic factors are still not well established. Programmed Death Ligand-1 (PD-L1) expression in ACC and its association with clinico-pathological features and survival outcomes are unknown. Formalin-fixed paraffin-embedded (FFPE) specimens were obtained from 28 patients with ACC. PD-L1 expression was evaluated by immunohistochemistry (IHC) in both tumor cell membrane and tumor infiltrating mononuclear cells (TIMC). PD-L1 positivity on tumor cells was defined as ≥5% tumor cell membrane staining. TIMC were evaluated by IHC using a CD45 monoclonal antibody. For PD-L1 expression in TIMC, a combined score based on the extent of infiltrates and percentage of positive cells was developed. Any score greater that zero was considered PD-L1 positive. Baseline clinico-pathological characteristics and follow up data were retrospectively collected. Comparisons between PD-L1 expression and clinico-pathological features were evaluated using unpaired t-test and Fisher's exact test. Kaplan-Meier method and log-rank test were used to assess association between PD-L1 expression and 5-year overall survival (OS). Among 28 patients with surgically treated ACC, 3 (10.7%) were considered PD-L1 positive on tumor cell membrane. On the other hand, PD-L1 expression in TIMC was performed in 27 specimens and PD-L1 positive staining was observed in 19 (70.4%) patients. PD-L1 positivity in either tumor cell membrane or TIMC was not significantly associated with higher stage at diagnosis, higher tumor grade, excessive hormone secretion, or OS. PD-L1 expression can exist in ACC in both tumor cell membrane and TIMC with no relationship to clinico-pathologic parameters or survival.