Details

Autor(en) / Beteiligte

• Hosoda, Kouichi
• Shimomura, Hirofumi
• Wanibuchi, Kiyofumi
• Masui, Hisashi
• Amgalanbaatar, Avarzed
• Hayashi, Shunji
• Takahashi, Takashi
• Hirai, Yoshikazu

Titel

Identification and characterization of a vitamin D3 decomposition product bactericidal against Helicobacter pylori

Ist Teil von

• Scientific reports, 2015-03, Vol.5 (1), p.8860-8860, Article 8860

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• This study demonstrated that the vitamin D 3 decomposition product VDP1 exerts an antibacterial action against Helicobacter pylori but not against other bacteria. Treatment with VDP1 induced a collapse of cell membrane structures of H. pylori and ultimately lysed the bacterial cells. A unique dimyristoyl phosphatidylethanolamine in the membrane lipid compositions contributed to the interaction of VDP1 with H. pylori cells. In separate experiments, VDP1 had no influence on the viability of the human cancer cell lines MKN45 and T47D and lacked any vitamin D 3 -like hormonal action against the latter. In both 1 H and 13 C NMR analyses, the spectra patterns of VDP1 corresponded with those of Grundmann's ketone. These results suggest that VDP1 (or Grundmann's ketone-type indene compound) may become a fundamental structure for the development of new antibacterial substances with selective bactericidal action against H. pylori .