Oncogene, 2015-07, Vol.34 (27), p.3547-3555
2015
Details
- Autor(en) / Beteiligte
- Titel
- A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer
- Ist Teil von
- Oncogene, 2015-07, Vol.34 (27), p.3547-3555
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Targeted cancer therapies, although often effective, have limited utility owing to preexisting primary or acquired secondary resistance. Consequently, agents are sometimes used in combination to simultaneously affect multiple targets. MicroRNA mimics are excellent therapeutic candidates because of their ability to repress multiple oncogenic pathways at once. Here we treated the aggressive Kras;p53 non-small cell lung cancer mouse model and demonstrated efficacy with a combination of two tumor-suppressive microRNAs (miRNAs). Systemic nanodelivery of miR-34 and let-7 suppressed tumor growth leading to survival advantage. This combinatorial miRNA therapeutic approach engages numerous components of tumor cell-addictive pathways and highlights the ability to deliver multiple miRNAs in a safe and effective manner to target lung tissue.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0950-9232eISSN: 1476-5594DOI: 10.1038/onc.2014.282Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4345154
- Format
- –
- Schlagworte
- Animals, Antineoplastic Combined Chemotherapy Protocols - therapeutic use, Carcinoma, Non-Small-Cell Lung - drug therapy, Carcinoma, Non-Small-Cell Lung - genetics, Carcinoma, Non-Small-Cell Lung - pathology, Cells, Combinatorics, Development and progression, Drug Delivery Systems, Drug therapy, Genes, Tumor Suppressor, Genetic aspects, Genetic Therapy - methods, Humans, Lung cancer, Lung cancer, Non-small cell, Lung Neoplasms - drug therapy, Lung Neoplasms - genetics, Lung Neoplasms - pathology, Methods, Mice, Mice, Transgenic, MicroRNA, MicroRNAs, MicroRNAs - administration & dosage, miRNA, Molecular targeted therapy, Nanostructures, Non-small cell lung carcinoma, p53 Protein, Properties, Ribonucleic acid, RNA, Small cell lung carcinoma, Tumor Burden - drug effects, Tumor Cells, Cultured, Xenograft Model Antitumor Assays