Neuropathology and applied neurobiology, 2015-02, Vol.41 (1), p.24-46
2015
Details
- Autor(en) / Beteiligte
- Titel
- Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging
- Ist Teil von
- Neuropathology and applied neurobiology, 2015-02, Vol.41 (1), p.24-46
- Ort / Verlag
- England: Blackwell Publishing Ltd
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- Wiley Online Library Journals Frontfile Complete
- Beschreibungen/Notizen
- Hereditary frontotemporal dementia associated with mutations in the microtubule‐associated protein tau gene (MAPT) is a protean disorder. Three neuropathologic subtypes can be recognized, based on the presence of inclusions made of tau isoforms with three and four repeats, predominantly three repeats and mostly four repeats. This is relevant for establishing a correlation between structural magnetic resonance imaging and positron emission tomography using tracers specific for aggregated tau. Longitudinal studies will be essential to determine the evolution of anatomical alterations from the asymptomatic stage to the various phases of disease following the onset of symptoms.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0305-1846eISSN: 1365-2990DOI: 10.1111/nan.12213Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4329416
- Format
- –
- Schlagworte
- [F18]-T807, Brain - diagnostic imaging, Brain - pathology, Female, Frontotemporal Dementia - diagnostic imaging, Frontotemporal Dementia - genetics, Frontotemporal Dementia - pathology, FTDP-17 MAPT, Humans, Inclusion Bodies - metabolism, Inclusion Bodies - pathology, Invited Reviews, Magnetic Resonance Imaging, Male, Medical research, Middle Aged, Mutation, neurofibrillary tangle, Phosphorylation, Pick body, Positron-Emission Tomography, Protein Isoforms - genetics, tau, tau aggregation, tau Proteins - genetics, tau Proteins - metabolism, Tomography, Emission-Computed